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. 2017 Oct 12;6(10):e002641. doi: 10.1161/JAHA.117.006593

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Uncoupling protein 2 (UCP2) inhibits in‐stent stenosis in coronary arteries of minipigs. A, Coronary angiography of Guizhou minipigs 3 months after bare‐metal stent implantation. The stented arterial segments were transfected with adenovirus expressing UCP2 and green fluorescent protein (GFP; Ad‐UCP2) or GFP alone (Ad‐GFP) through a local drug infusion balloon catheter. Red arrow indicates stenosis. B, Hematoxylin and eosin (H&E)–stained sections of porcine coronary arteries distal to the stents. Bar=100 μm. C, H&E‐stained sections of stented coronary arteries. Bar=500 μm. D, In‐stent stenosis of coronary arteries transfected with Ad‐GFP or Ad‐UCP2. n=5. **P<0.01.