Table 5.
Adjusted HRs and 95% CI of cumhs‐CRP for End Point Events by Cox Proportional Hazards Models (Sensitive Analyses)
| Variables | HR (95% CI) | ||||
|---|---|---|---|---|---|
| CVD | MI | Stroke | Hemorrhagic Stroke | Ischemic Stroke | |
| Model 4 | |||||
| Nonexposed | |||||
| 1‐exposed | 1.11 (0.95–1.30) | 1.50 (1.01–2.05) | 1.01 (0.85–1.22) | 1.12 (0.73–1.74) | 1.01 (0.83–1.23) |
| 2‐exposed | 1.29 (1.06–1.58) | 1.69 (1.14–2.52) | 1.18 (0.93–1.49) | 1.37 (0.79–2.39) | 1.13 (0.88–1.46) |
| 3‐exposed | 1.39 (1.04–1.86) | 2.28 (1.36–3.81) | 1.17 (0.83–1.66) | 0.66 (0.20–2.12) | 1.23 (0.85–1.77) |
| P trend | 0.015 | 0.002 | 0.410 | 0.547 | 0.507 |
| cumhs‐CRP (+1 SD) | 1.38 (1.14–1.66) | 2.12 (1.51–2.99) | 1.17 (0.94–1.46) | 1.10 (0.63–1.92) | 1.16 (0.91–1.48) |
| Model 5 | |||||
| Nonexposed | |||||
| 1‐exposed | 1.14 (0.98–1.32) | 1.60 (1.20–2.15) | 1.02 (0.86–1.22) | 1.07 (0.90–1.63) | 1.03 (0.86–1.25) |
| 2‐exposed | 1.26 (1.05–1.51) | 1.54 (1.07–2.21) | 1.17 (0.95–1.44) | 1.56 (0.97–2.49) | 1.11 (0.88–1.40) |
| 3‐exposed | 1.40 (1.12–1.75) | 2.20 (1.47–3.29) | 1.17 (0.89–1.53) | 0.99 (0.49–2.00) | 1.20 (0.90–1.62) |
| P trend | 0.009 | <0.001 | 0.403 | 0.278 | 0.623 |
| cumhs‐CRP (+1 SD) | 1.04 (0.99–1.09) | 1.07 (1.00–1.14) | 1.03 (0.96–1.09) | 0.96 (0.78–1.19) | 1.03 (0.97–1.10) |
| Model 6 | |||||
| Nonexposed | |||||
| 1‐exposed | 1.10 (0.91–1.34) | 1.41 (0.97–2.03) | 1.01 (0.80–1.27) | 1.28 (0.73–2.26) | 1.00 (0.78–1.28) |
| 2‐exposed | 1.25 (0.98–1.59) | 1.37 (0.85–2.21) | 1.18 (0.89–1.57) | 1.79 (0.94–3.42) | 1.09 (0.78–1.51) |
| 3‐exposed | 1.57 (1.17–2.10) | 2.17 (1.27–3.69) | 1.34 (0.94–1.91) | 1.55 (0.65–3.69) | 1.35 (0.90–2.02) |
| P trend | 0.020 | 0.032 | 0.313 | 0.338 | 0.517 |
| cumhs‐CRP (+1 SD) | 1.06 (1.00–1.13) | 1.07 (0.97–1.18) | 1.06 (0.99–1.13) | 1.04 (0.87–1.26) | 1.06 (0.98–1.14) |
P trend: test of trend based on median value in each category for ordinal categorical variables. Model 4: Model 3 excluding the subjects with hs‐CRP≥10 mg/L during 3 examinations. Model 5: Model 4 excluding subjects under treatment of lipid‐lowering medication. Model 6: Model 5 excluding subjects under treatment of antihypertensive medication. CI indicates confidence interval; cumhs‐CRP, cumulative high‐sensitivity C‐reactive protein; CVD, cardiovascular disease; HR, hazard ratio; MI, myocardial infarction.