Table 3.
Discriminatory Power of Prediction Models for Men and Women Combined
| Variables Added | C‐Statistic (95% Confidence Interval) | ||
|---|---|---|---|
| GRACE | TIMIa | Age and Sex | |
| Overall: 1401 subjects (190 deaths) | |||
| None | 0.80 (0.77–0.83) | 0.63 (0.59–0.67) | 0.74 (0.70–0.77) |
| Charlson index | 0.82 (0.79–0.84)b | 0.75 (0.72–0.78)c | 0.79 (0.76–0.82)c |
| sST2 | 0.86 (0.84–0.88)c | 0.83 (0.81–0.85)c | 0.85 (0.82–0.87)c |
| STEMI only: 291 subjects (26 deaths) | |||
| None | 0.89 (0.84–0.93) | 0.80 (0.72–0.89) | 0.78 (0.69–0.88) |
| Charlson index | 0.90 (0.83–0.96) | 0.85 (0.76–0.93) | 0.84 (0.75–0.92) |
| sST2 | 0.94 (0.90–0.97)b | 0.91 (0.87–0.96)b | 0.92 (0.88–0.96)b |
| NSTEMI only: 1110 subjects (164 deaths) | |||
| None | 0.78 (0.74–0.81) | 0.61 (0.57–0.65) | 0.72 (0.68–0.76) |
| Charlson index | 0.80 (0.76–0.83)b | 0.73 (0.69–0.77)c | 0.77 (0.74–0.81)c |
| sST2 | 0.84 (0.81–0.87)c | 0.81 (0.79–0.84)c | 0.83 (0.80–0.86)c |
sST2 and Charlson comorbidity index are log transformed and modeled as continuous variables, along with age. GRACE indicates Global Registry of Acute Coronary Events; NSTEMI, non–ST‐elevation myocardial infarction; sST2, soluble suppression of tumorigenicity‐2; STEMI, ST‐elevation myocardial infarction; and TIMI, Thrombolysis in Myocardial Infarction.
a
Specific TIMI scores were used for STEMI/NSTEMI, as appropriate.
b
P≤0.05 for comparison with previous (ie, above) model.
c
P≤0.01 for comparison with previous (ie, above) model.