Table 5.
Discriminatory Power of Prediction Models for Women
| Variables Added | C‐Statistic (95% Confidence Interval) | ||
|---|---|---|---|
| GRACE | TIMIa | Age | |
| Overall: 548 subjects (91 deaths) | |||
| None | 0.75 (0.69–0.80) | 0.57 (0.51–0.62) | 0.69 (0.63–0.75) |
| Charlson index | 0.77 (0.72–0.83) | 0.68 (0.63–0.74)b | 0.74 (0.68–0.79)b |
| sST2 | 0.83 (0.79–0.86)b | 0.80 (0.76–0.84)b | 0.81 (0.78–0.85)b |
| STEMI only: 82 subjects (12 deaths) | |||
| None | 0.82 (0.65–0.98) | 0.71 (0.55–0.87) | 0.70 (0.53–0.86) |
| Charlson index | 0.85 (0.73–0.98) | 0.78 (0.64–0.92) | 0.79 (0.67–0.91) |
| sST2 | 0.88 (0.79–0.97) | 0.87 (0.77–0.97) | 0.87 (0.77–0.97) |
| NSTEMI only: 466 subjects (79 deaths) | |||
| None | 0.73 (0.67–0.80) | 0.55 (0.48–0.63) | 0.69 (0.62–0.75) |
| Charlson index | 0.76 (0.70–0.82) | 0.67 (0.61–0.73)b | 0.73 (0.67–0.80)b |
| sST2 | 0.81 (0.77–0.86)b | 0.78 (0.74–0.83)b | 0.81 (0.76–0.86)b |
sST2 and Charlson comorbidity index are log transformed and modeled as continuous variables, along with age. GRACE indicates Global Registry of Acute Coronary Events; NSTEMI, non–ST‐elevation myocardial infarction; sST2, soluble suppression of tumorigenicity‐2; STEMI, ST‐elevation myocardial infarction; and TIMI, Thrombolysis in Myocardial Infarction.
a
Specific TIMI scores were used for STEMI/NSTEMI, as appropriate.
b
P≤0.01 for comparison with previous (ie, above) model.