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. 2017 Oct 5;6(10):e006135. doi: 10.1161/JAHA.117.006135

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© 2017 The Authors and Sarfez Pharmaceuticals, Inc. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Excretion of fluid (UV; A), sodium (U_NaV; B) and potassium (U_KV; C); creatinine clearance (C_CR; D); body weight (BWt; E); and mean blood pressure (MBP; F). Individual paired values for the changes in the 24 hours after torsemide from the prior 24 hours, comparing immediate‐release (IM) (open boxes) and extended‐release (ER) (crosshatched boxes) torsemide and differences (solid boxes) in the changes produced by torsemide ER vs IR. Significance of difference from prior, prediuretic day: *P<0.05; ***P<0.005. Significance of difference between changes with ER vs IR: ^† P<0.05.