Table 1.
Pharmocokinetic Parameters After Administration of Torsemide
| IR or ER Torsemide | |||
|---|---|---|---|
| Parameter | IR | ER | P Value |
| CMAX, ng·mL−1 | 2962±412 | 905±93 | <0.001 |
| AUC0‐t, h*·ng·mL−1 | 6493±688 | 5125±552 | <0.001 |
| AUCo‐inf, h*·ng·mL−1 | 6728±704 | 5543±565 | <0.001 |
| Tmax, h | 1.03±0.13 | 3.53±0.27 | <0.001 |
| AUC1–3, h*·ng·mL−1 | 2966±294 | 1225±161 | <0.001 |
| AUC8–10, h*·ng·mL−1 | 203±32 | 400±50 | <0.001 |
Mean±SEM values (n=10 per group). AUC indicates area under the curve; cmax, peak serum concentration; ER, extended‐release; IR, immediate‐release; Tmax, time to reach peak serum concentration.