Figure 10.

DPP4 inhibition ameliorates EPC production and mobilization in stressed mice. A, Representative dot plots and quantitative data for the numbers of CD31⁺/c‐Kit⁺ (per 2×10⁴ cells) in BM and PB (n=5–6, Mann–Whitney U test). B through D, BM‐derived c‐Kit⁺ cells were subjected to proliferation (B), apoptosis (C), and tubule formation (D) assays (Student t test). Data are mean±SE (n=5–7). *P<0.01 by ANOVA and Tukey's post hoc tests or Student t test. BM indicates bone marrow; DPP4, dipeptidyl peptidase‐4; EPC, endothelial progenitor cell; PB, peripheral blood; TUNEL, TdT‐mediated dUTP nick‐end labeling.