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. 2017 Sep 28;6(10):e006421. doi: 10.1161/JAHA.117.006421

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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DPP4 inhibition decreased inflammation and MMP activity. A and B, Representative gelatin zymographic images showing the levels of MMP‐2 and MMP‐9 gelatinolytic activities in the nonischemic and ischemic muscles of stressed mice (A) and rats (B) at the noted days after ischemic surgery. C, Representative microscopy images and quantitative data for the macrophage infiltration. Data are mean±SE (n=6‐7). *P<0.01 vs DPP4^+/+ by ANOVA and Tukey's post hoc test. Scale bar, 50 μm. DPP4 indicates dipeptidyl peptidase‐4; MMP‐2, matrix metalloproteinase‐2; NS, not significant.