Table 3.
Levels of Lipids and Other Parameters in the 3 Experimental Groups at 7 Weeks
| Parameter | Stress | S‐DL | S‐DH |
|---|---|---|---|
| Body weight, g | 21.5±0.3 | 20.5±0.4 | 21.8±0.3 |
| Triglyceride, mg/dL | 17.1 ±1.9 | 16.0±2.4 | 19.2±1.7 |
| TCh, mg/dL | 48.2±4.1 | 47.7±3.9 | 43.9±4.5 |
| HDL‐C, mg/dL | 30.3±1.9 | 32.3±1.3 | 32.1±1.6 |
| NEFA, μEQ/L | 1204±61 | 777±61a | 758±39a |
| Blood urea nitrogen, mg/dL | 29.7± 1.9 | 31.3 ±1.6 | 30.4±1.3 |
| Creatinine, mg/dL | 0.2±0.0 | 0.2±0.0 | 0.2±0.0 |
| Glucose, mg/mL | 101.2±5.6 | 85.5±5.2a | 82.8±4.9a |
| Corticosterone, ng/mL | 80.3±6.1 | 105.6±12.2a | 113.4±10.9a |
| Real‐time PCR (adipose) | |||
| IRS‐1 | 10.4±1.8 | 45.8 ±5.3a | 42.4±3.3a |
| GLUT4 | 16.2±2.7 | 34.5±6.8a | 39.8±4.1a |
Values are mean±SE (n=6–10). GLUT4 indicates glucose transporter 4; HDL‐C, high‐density lipoprotein cholesterol; IRS‐1, insulin receptor substrate 1; NEFA, nonesterified fatty acid; PCR, polymerase chain reaction; S‐DH, stressed mice received high dose of DPP4 inhibitor; S‐DL, stressed mice received low dose of dipeptidyl peptidase 4 inhibitor; TCh, total cholesterol.
a
P<0.05 vs stress alone mice by analysis of variance and Tukey's post hoc test.