Table 1.
Body and Organ Weights After KI Treatment
| Treatment (n) | Body Weight, Initial (g) | Body Weight, Final (g) | Heart Weight (mg) | Heart/Body Weight (%) | Lung Weight (mg) | Lung Weight/Body Weight (%) |
|---|---|---|---|---|---|---|
| Vehicle (4) | 21.9±0.7 | 21.2±0.4 | 84±4 | 0.40±0.01 | 119±5 | 0.56±0.01 |
| Erlotinib 50 mg/kg per d (5) | 21.1±0.4 | 19.5±0.7 | 87±2 | 0.45±0.02a | 115±3 | 0.59±0.03 |
| Sunitinib 40 mg/kg per d (5) | 20.9±0.5 | 19.9±0.6 | 82±3 | 0.41±0.02 | 128±3a | 0.64±0.03a |
| Sorafenib 30 mg/kg per d (5) | 21.9±0.5 | 20.2±0.2a | 93±3 | 0.46±0.01a | 125±6 | 0.62±0.02a |
KI indicates kinase inhibitor.
All values are mean±SEM, n given in parentheses.
a
P<0.05 vs vehicle treatment.