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. 2017 Oct 19;6(10):e006680. doi: 10.1161/JAHA.117.006680

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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PHD3 overexpression improve EndMT‐induced morphologic alteration, enhanced migration, and collagen secretion. A, Morphological changes in HUVECs were observed by microscopy. Representative images of crystal violet staining (purple; original magnification, ×100; bars=50 μm). B, Quantification of crystal violet staining. C, Western blot analysis and quantification of Collagen I (c1 and c2) and Collagen III (c1 and c3). *P<0.05 vs control; **P<0.01 vs control; ^# P<0.05 vs IH+LvNC; ^## P<0.01 vs IH+LvNC. EndMT indicates endothelial‐to‐mesenchymal transition; HUVECs, human umbilical vein endothelial cells; IH, intermittent hypoxia; PHD3, prolyl 4‐hydroxylase domain protein 3.