Table 3.
Arterial Function Measures at Baseline and Follow‐up (Adjusted for Age, Sex, and Ethnicity) by Treatment Group Among Those With Baseline Vitamin D Deficiency (Deseasonalized 25(OH)D <50 nmol/L; n=150)
| Variable | Mean (SD) | Change From Baseline, Vitamin D Minus Placebo | ||||
|---|---|---|---|---|---|---|
| Vitamin D Group (n=71) | Placebo Group (n=79) | |||||
| Baseline | Follow‐up | Baseline | Follow‐up | Mean (95% CI) | P Value | |
| Pulse rate, beats/min | 62.9 (10.9) | 65.7 (9.9) | 66.2 (13.3) | 65.4 (12.8) | 3.5 (−0.0 to 7.1) | 0.05 |
| Brachial SBP, mm Hg | 137.4 (16.8) | 125.5 (13.0) | 139.4 (18.2) | 132.8 (20.1) | −5.3 (−11.8 to 1.3) | 0.11 |
| Brachial DBP, mm Hg | 78.9 (10.7) | 72.8 (9.2) | 80.0 (11.3) | 76.6 (10.8) | −2.8 (−6.2 to 0.7) | 0.12 |
| Aortic SBP, mm Hg | 139.8 (18.5) | 127.1 (14.1) | 141.1 (18.6) | 136.0 (21.4) | −7.5 (−14.4 to −0.6) | 0.03 |
| Aortic DBP, mm Hg | 72.2 (6.4) | 68.9 (5.5) | 73.2 (7.0) | 71.3 (6.5) | −1.3 (−3.7 to 1.0) | 0.25 |
| Augmentation index, % | 29.7 (13.6) | 22.9 (8.7) | 29.1 (13.7) | 28.1 (14.5) | −5.7 (−10.8 to −0.6) | 0.03 |
| Pulse wave velocity, m/s | 9.2 (1.8) | 8.9 (1.5) | 9.2 (1.9) | 9.3 (2.0) | −0.3 (−0.6 to −0.1) | 0.02 |
| Peak reservoir pressure, mm Hg | 125.2 (18.0) | 112.3 (12.4) | 125.2 (17.9) | 120.9 (20.1) | −8.6 (−15.4 to −1.9) | 0.01 |
| Peak excess pressure, mm Hg | 26.5 (6.8) | 25.7 (8.4) | 28.6 (8.7) | 27.0 (7.9) | 0.7 (−2.8 to 4.1) | 0.70 |
| Reservoir pressure integral, mm Hg/s | 93.0 (19.1) | 81.2 (16.2) | 89.5 (21.2) | 87.5 (23.1) | −9.8 (−16.2 to −3.3) | 0.003 |
| Loge(excess pressure integral, mm Hg/s) | 1.51 (0.39) | 1.38 (0.47) | 1.54 (0.42) | 1.45 (0.43) | −0.04 (−0.22 to 0.14) | 0.65 |
| Backward pressure amplitude, mm Hg | 28.7 (8.0) | 23.5 (6.0) | 28.4 (7.7) | 26.7 (9.1) | −3.6 (−6.3 to −0.8) | 0.01 |
| Forward pressure amplitude, mm Hg | 39.7 (8.8) | 34.7 (6.3) | 40.1 (8.7) | 38.4 (9.9) | −3.3 (−6.4 to −0.2) | 0.04 |
| Loge(wave reflection index), ×10−2 | −117.7 (34.2) | −130.6 (31.3) | −122.6 (41.8) | −125.1 (50.2) | −10.3 (−29.2 to 8.6) | 0.28 |
CI indicates confidence interval; DBP, diastolic blood pressure; SBP, systolic blood pressure.