Table 2.
Baseline Comparison of the RDN and Control Groups in the CT Angiogram Substudy
| All | RDN | Control | P Valuea | |
|---|---|---|---|---|
| n=90 | n=42 | n=48 | ||
| Clinical characteristics | ||||
| Age, y | 54.6±10.6 | 54.5±11.1 | 54.6±10.3 | 0.9817 |
| Male | 55 (61.1) | 26 (61.9) | 29 (60.4) | 0.8851 |
| White | 69 (76.7) | 33 (78.6) | 36 (75.0) | 0.6894 |
| Nonsmokers | 44 (48.9) | 20 (47.6) | 24 (50.0) | 0.3373 |
| Type 2 diabetes mellitus | 20 (22.2) | 7 (16.7) | 13 (27.1) | 0.2357 |
| Hyperlipidemia | 39 (43.3) | 19 (45.2) | 20 (41.7) | 0.7330 |
| Prior cardiovascular event | 21 (23.3) | 13 (31.0) | 8 (16.7) | 0.1099 |
| Prior stoke | 8 (8.9) | 5 (11.9) | 3 (6.3) | 0.4654 |
| Obstructive sleep apnea | 27 (30.0) | 14 (33.3) | 13 (27.1) | 0.5186 |
| BMI, kg/m2 | 30.5±4.8 | 30.8±5.2 | 30.2±4.4 | 0.5307 |
| Biological characteristics | ||||
| Plasma creatinine, μmol/L | 83.4±23.6 | 83.2±22.7 | 83.6±24.6 | 0.9481 |
| eGFR, mL/min/1.73 m2 | 89.8±24.5 | 89.9±25.2 | 89.8±24.1 | 0.9845 |
| Cardiovascular parameters | ||||
| Office SBP, mm Hg | 157.0±21.1 | 159.0±22.1 | 155.3±20.3 | 0.4023 |
| Office DBP, mm Hg | 92.3±14.2 | 94.0±15.1 | 90.9±13.4 | 0.3140 |
| Office HR, beats/min | 72.4±11.2 | 71.5±10.6 | 73.2±11.8 | 0.4691 |
| Daytime ambulatory SBP, mm Hg | 153.5±16.5 | 155.9±16.7 | 151.4±16.2 | 0.1960 |
| Daytime ambulatory DBP, mm Hg | 92.8±13.3 | 93.5±15.6 | 92.3±11.1 | 0.6816 |
| Daytime ambulatory PP, mm Hg | 60.7±14.2 | 62.5±14.3 | 59.1±14.0 | 0.2619 |
| Nighttime ambulatory SBP, mm Hg | 139.2±16.4 | 142.8±17.7 | 136.0±14.7 | 0.0478 |
| Nighttime ambulatory DBP, mm Hg | 81.3±13.8 | 83.4±16.4 | 79.4±10.9 | 0.1715 |
| Nighttime ambulatory PP, mm Hg | 57.9±13.1 | 59.4±12.9 | 56.6±13.4 | 0.3082 |
| 24‐h ambulatory SBP, mm Hg | 149.7±16.2 | 152.4±16.9 | 147.3±15.4 | 0.1400 |
| 24‐h ambulatory DBP, mm Hg | 89.9±13.3 | 90.8±15.7 | 89.0±10.9 | 0.5178 |
| 24‐h ambulatory PP, mm Hg | 59.8±13.7 | 61.5±13.7 | 58.3±13.7 | 0.2675 |
| PWV, m/s | 11.3±2.9 | 11.7±2.8 | 11.0±3.0 | 0.2964 |
| AAC, cm3 | ||||
| All | 0.448 (0.098–2.055) | 0.433 (0.012–2.310) | 0.7954 | |
| Tertile 1 | 30 (33.3) | 13 (31.0) | 17 (35.4) | 0.3916 |
| Tertile 2 | 30 (33.3) | 17 (40.5) | 13 (27.1) | |
| Tertile 3 | 30 (33.3) | 12 (28.6) | 18 (37.5) | |
Data are expressed as mean±SD, n (%), or median (interquartile range). AAC indicates abdominal aortic calcifications; BMI, body mass index; CT, computed tomography; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HR, heart rate; PP, pulse pressure; PWV, pulse wave velocity; RDN, renal denervation; SBP, systolic blood pressure.
a
P values were obtained by unpaired t tests and Mann–Whitney U tests for continuous variables and by χ2 and Fisher exact tests for discrete variables.