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Plasma estradiol and leptin levels in young and old male SHR with or without testosterone supplements. A, Testosterone supplements increased plasma estradiol in young male SHR (YMSHR) but had no effect in old male SHR (OMSHR). *P<0.05 vs YMSHR‐P (placebo); # P<0.05 vs YMSHR‐T (testosterone). B, Testosterone supplements reduced plasma leptin in YMSHR but had no effect on OMSHR. *P<0.05 vs YMSHR‐P. SHR indicates spontaneously hypertensive rats.
