Fig. 1.

Mouse serum cholesterol levels with simvastatin (SMV), pravastatin (PRV), or atorvastatin (ATV) treatment. Total serum cholesterol was measured in statin-treated and untreated mice after 150 days of consuming statin-supplemented or control chow. There was a ≥40 % reduction in the average cholesterol in all three statins tested relative to control, indicating an effect on the mevalonate pathway. Each dot represents a single mouse. Error bars indicate one standard deviation. *** P value ≤0.001 by one-way ANOVA relative to untreated.