Table 3. Inflammatory genes significantly altered with statin treatment of 22L-infected mice compared to untreated 22L-infected control mice.

		Simvastatin	Pravastatin	Atorvastatin
Gene	Increased in scrapie [5]	FC†	FC	FC	Description
Ccl2	Yes	2.5*	1.5	1.7	Chemokine (C-C motif) ligand 2
Cxcl11	Yes	1.6	−2.1*	−1.1	Chemokine (C-X-C motif) ligand 11
Cxcl13	Yes	2.3*	2.0*	1.6	Chemokine (C-X-C motif) ligand 13
Cxcr3	Yes	−1.6	−1.9	−4.0*	Chemokine (C-X-C motif) receptor 3
Cxcr5	Yes	1.1	−2.7*	−1.8	Chemokine (C-X-C motif) receptor 5
Osm	Yes	−1.1	−4.3*	−1.5	Oncostatin M
Tnf	Yes	1.2	−2.5*	−1.5	Tumour necrosis factor
Csf3	No	1.2	−2.7***	−1.2	Colony stimulating factor 3
Il3	No	−1.1	−2.8*	−1.8	Interleukin 3
Tnfsf4	No	1.1	−2.3*	−1.5	Tumour necrosis factor superfamily, member 4

Bold numerals represent significant changes that met our criteria of a minimum twofold change.

Underlined bold numerals are changes where treatment increased chemokine expression.

†Fold change in gene expression in infected statin-treated versus infected untreated mice.

* P value ≤ 0.05, ***P value ≤0.001.