Table 3.
Genotype frequencies of SNPs within COMT, DRD1, DRD2, DRD3, and DRD5
| Gene | Genotype (W>M) | Control (n=430) | Cases (n=690) |
|---|---|---|---|
| COMT | rs165599 A>G | ||
| AA | 139 (32.32%) | 212 (30.72%) | |
| AG | 231 (53.72%) | 367 (53.19%) | |
| GG | 60 (13.96%) | 111 (16.19%) | |
| χ2 | Ref | 1.020 | |
| P-value | Ref | 0.600 | |
| rs4680 G>A | |||
| GG | 211 (49.07%) | 297 (43.04%) | |
| GA | 172 (40.00%) | 310 (44.93%) | |
| AA | 47 (10.93%) | 83 (12.03%) | |
| χ2 | Ref | 3.891 | |
| P-value | Ref | 0.143 | |
| rs165774 G>A | |||
| GG | 317 (73.72%) | 399 (57.83%) | |
| AG | 106 (24.65%) | 238 (34.49%) | |
| AA | 7 (1.63%) | 53 (7.68%) | |
| χ2 | Ref | 36.94 | |
| P-value | Ref | <0.001 | |
| DRD1 | rs11746641 T>G | ||
| TT | 311 (72.32%) | 354 (51.30%) | |
| TG | 113 (26.28%) | 283 (41.01%) | |
| GG | 6 (1.40%) | 53 (7.69%) | |
| χ2 | Ref | 55.85 | |
| P-value | Ref | <0.001 | |
| rs11749676 G>A | |||
| GG | 152 (35.34%) | 387 (56.09%) | |
| GA | 211 (49.07%) | 238 (34.49%) | |
| AA | 67 (15.59%) | 65 (9.42%) | |
| χ2 | Ref | 46.25 | |
| P-value | Ref | <0.001 | |
| DRD2 | rs6275 C>T | ||
| CC | 86 (20.00%) | 154 (22.32%) | |
| CT | 211 (49.07%) | 335 (48.55%) | |
| TT | 133 (30.93%) | 201 (29.13%) | |
| χ2 | Ref | 0.967 | |
| P-value | Ref | 0.617 | |
| rs1801028 C>G | |||
| CC | 396 (92.09%) | 632 (91.59%) | |
| CG | 26 (6.05%) | 51 (7.39%) | |
| GG | 8 (1.86%) | 7 (1.02%) | |
| χ2 | Ref | 2.12 | |
| P-value | Ref | 0.346 | |
| rs6277 C>T | |||
| CC | 410 (95.35%) | 554 (80.29%) | |
| CT | 13 (3.02%) | 109 (15.80%) | |
| TT | 7 (1.63%) | 27 (3.91%) | |
| χ2 | Ref | 51.22 | |
| P-value | Ref | <0.001 | |
| DRD3 | rs6280 T>C | ||
| TT | 363 (84.42%) | 418 (60.58%) | |
| TC | 46 (10.70%) | 212 (30.72%) | |
| CC | 21 (4.88%) | 60 (8.70%) | |
| χ2 | Ref | 10.489 | |
| P-value | Ref | <0.001 | |
| DRD5 | rs6283 T>C | ||
| TT | 145 (33.72%) | 212 (30.72%) | |
| TC | 218 (50.70%) | 348 (50.43%) | |
| CC | 67 (15.58%) | 130 (18.85%) | |
| χ2 | Ref | 2.350 | |
| P-value | Ref | 0.309 |
Abbreviations: COMT, catechol-O-methyltransferase; DRD1, dopamine receptor D1; DRD2, dopamine receptor D2; DRD3, dopamine receptor D3; DRD5, dopamine receptor D5; M, mutant allele; Ref, Reference; SNP, single nucleotide polymorphism; W, wild allele.