Table 4.
Association between COMT and dopamine receptor SNPs and schizophrenia risk under five genetic models
| Gene | SNP (W>M) | Allelic model M vs W
|
Heterozygous model WM vs WW
|
Homozygous model MM vs WW
|
Dominant model WM+MM vs WW
|
Recessive model MM vs WW+WM
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AORa (95% CI) | P-value | AORa (95% CI) | P-value | AORa (95% CI) | P-value | AORa (95% CI) | P-value | AORa (95% CI) | P-value | ||
| COMT | rs165599 A>G | 1.08 (0.91–1.28) | 0.384 | 1.16 (0.82–1.66) | 0.400 | 1.21 (0.83–1.77) | 0.319 | 1.08 (0.83–1.40) | 0.574 | 1.18 (0.84–1.66) | 0.334 |
| rs4680 G>A | 1.18 (0.98–1.41) | 0.081 | 0.98 (0.66–1.47) | 0.921 | 1.26 (0.84–1.87) | 0.265 | 1.28 (1.00–1.62) | 0.049 | 1.11 (0.76–1.63) | 0.577 | |
| rs165774 G>A | 2.05 (1.63–2.57) | <0.001* | 3.37 (1.48–7.66) | 0.002* | 6.02 (2.70–13.41) | <0.001* | 2.05 (1.57–2.66) | <0.001* | 5.03 (2.26–11.16) | <0.001* | |
| DRD1 | rs11746641 T>G | 2.31 (1.85–2.89) | <0.001* | 3.53 (1.48–8.44) | <0.001* | 7.76 (3.29–18.30) | <0.001* | 2.48 (1.92–3.21) | <0.001* | 5.88 (2.51–13.80) | <0.001* |
| rs11749676 G>A | 0.54 (0.45–0.65) | <0.001* | 0.38 (0.26–0.56) | <0.001* | 0.86 (0.58–1.27) | 0.447 | 0.43 (0.33–0.55) | <0.001* | 0.56 (0.39–0.81) | 0.002* | |
| DRD2 | rs6275 C>T | 0.92 (0.78–1.09) | 0.341 | 0.95 (0.72–1.26) | 0.729 | 0.84 (0.60–1.19) | 0.332 | 0.87 (0.65–1.17) | 0.358 | 0.92 (0.71–1.19) | 0.522 |
| rs1801028 C>G | 0.96 (0.65–1.43) | 0.851 | 0.45 (0.15–1.37) | 0.151 | 0.55 (0.20–1.52) | 0.242 | 1.07 (0.69–1.66) | 0.767 | 0.54 (0.20–1.50) | 0.231 | |
| rs6277 C>T | 4.13 (2.72–6.27) | <0.001* | 0.46 (0.17–1.26) | 0.126 | 2.86 (1.23–6.62) | 0.011 | 5.03 (3.09–8.18) | <0.001* | 2.46 (1.06–5.70) | 0.030 | |
| DRD3 | rs6280 T>C | 2.78 (2.16–3.58) | <0.001* | 0.62 (0.34–1.12) | 0.110 | 2.48 (1.48–4.16) | <0.001* | 3.53 (2.61–4.77) | <0.001* | 1.86 (1.11–3.10) | 0.017 |
| DRD5 | rs6283 T>C | 1.14 (0.96–1.35) | 0.146 | 1.22 (0.87–1.71) | 0.260 | 1.33 (0.92–1.91) | 0.126 | 1.15 (0.89–1.48) | 0.295 | 1.26 (0.91–1.74) | 0.164 |
Notes:
*
Statistical significance.
a
AOR for gender, age, and other clinical characteristics.
Abbreviations: AOR, adjusted odds ratio; COMT, catechol-O-methyltransferase; DRD1, dopamine receptor D1; DRD2, dopamine receptor D2; DRD3, dopamine receptor D3; DRD5, dopamine receptor D5; M, mutant allele; SNP, single nucleotide polymorphism; W, wild allele.