Table 2.
Dynamics of insulin resistance markers in patients with myocardial infarction during therapy with atorvastatin
| Variables | Controls (n=40) (1) | Group 1
|
Group 2
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Day 1 (2) | Day 12 (3) | 3 months (4) | 1 year (5) | Day 1 (6) | Day 12 (7) | 3 months (8) | 1 year (9) | ||
| Glucose (mmol/L) | 5.05 (4.90; 5.35) | 6.2 (5.5; 8.1) P1,2=0.0001 |
5.2 (4.80; 6.20) P1,3=0.05 P2,3=0.001 |
5.3 (4.90; 5.82) | 5.5 (4.71; 6.20) | 6.3 (5.30; 7.10) P1,6=0.0003 |
5.6 (5.00; 6.20) P1,7=0.007 P6,7=0.001 |
5.5 (5.02; 6.21) P1,8=0.003 |
5.9 (5.01; 7.42) P1,9=0.0001 P5,9=0.024 P8,9=0.002 |
| Insulin (mU/mL) | 9.62 (7.60; 12.20) | 12.95 (8.50; 14.60) P1,2=0.045 |
11.75 (7.50; 16.00) | 10.2 (8.10; 14.12) P2,4=0.004 P3,4=0.005 |
9.96 (7.40; 12.70) | 12.5 (8.90; 15.92) P1,6=0.014 |
10.81 (6.40; 16.05) P3,7=0.005 P6,7=0.019 |
11.46 (9.70; 13.26) P4,8=0.013 |
12.67 (9.74; 15.70) P1,9=0.01 P5,9=0.001 P8,9=0.03 |
| C-peptide (ng/mL) | 1.75 (1.41; 2.10) | 2.16 (1.55; 2.75) P1,2=0.042 |
2.11 (1.47; 2.66) | 1.93 (1.44; 2.31) P3,4=0.005 |
1.97 (1.47; 2.34) | 2.15 (1.60; 3.11) P1,6=0.032 |
1.87 (1.41; 3.09) P3,7=0.221 P6,7=0.008 |
2.03 (1.75; 2.93) P1,8=0.02 P4,8=0.174 P7,8=0.07 |
2.29 (1.72; 3.98) P1,9=0.01 P8,9=0.04 |
| QUICKI | 0.380 (0.374; 0.385) | 0.309 (0.306; 0.311) P1,2=0.0002 |
0.319 (0.313; 0.320) P2,3=0.011 |
0.363 (0.359; 0.370) P3,4=0.002 |
0.375 (0.371; 0.379) | 0.306 (0.302; 0.308) P1,6=0.004 |
0.336 (0.320; 0.361) P6,7=0,002 |
0.313 (0.309; 0.319) P1,8=0.153 |
0.301 (0.298; 0.303) P1.9=0.024 P5.9=0.044 P7.9=0.035 P8.9=0.026 |
Notes: Group 1: atorvastatin at a dose of 20 mg/day. Group 2: atorvastatin at a dose of 40 mg/day. Results are presented as median (Me) and 25% and 75% quartiles: Me (Q1;Q3). Numbers 1–9 shown in parentheses in the column headings correspond with the subscript numbers 1–9 shown next to the P-values.
Abbreviation: QUICKI, quantitative insulin sensitivity check index.