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. 2017 Dec 5;12:8649–8670. doi: 10.2147/IJN.S147591

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© 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited

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The in vitro synergistic effects of PDFI nanoparticles/laser irradiation combined with PDFP nanoparticles in MHCC-97H cells.

Notes: (A) The cytotoxicities of free PTX at different concentrations after treatments for 48 h. (B) The cytotoxicities of PDFP nanoparticles combined with and without PDFI nanoparticles/laser irradiation (PDFI/L) at different PTX concentrations after treatments for 48 h. The IR780 concentration was 1 μg/mL. The laser irradiation was carried out at 808 nm with a powder density of 2 W/cm² for 2 min. *p<0.05 and **p<0.01 for comparing these two treatment groups. (C) The apoptosis of cells at 48 h after various treatments (Q1: dead cells; Q2: late apoptotic cells; Q3: early apoptotic cells; Q4: live cells). (D) The cell cycle distributions at 48 h after various treatments. The concentrations of IR780 and PTX were 1.5 and 5 μg/mL, respectively, and all experiments were repeated at least 3 times.

Abbreviations: DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; PDFI, pullulan coated IR780-loaded DOPE/PF68 complex nanocore; PDFP, pullulan coated paclitaxel-loaded DOPE/PF68 complex nanocore; PF68, Pluronic F68; PTX, paclitaxel; FITC, fluorescein isothiocyanate.

The in vitro synergistic effects of PDFI nanoparticles/laser irradiation combined with PDFP nanoparticles in MHCC-97H cells.

Notes: (A) The cytotoxicities of free PTX at different concentrations after treatments for 48 h. (B) The cytotoxicities of PDFP nanoparticles combined with and without PDFI nanoparticles/laser irradiation (PDFI/L) at different PTX concentrations after treatments for 48 h. The IR780 concentration was 1 μg/mL. The laser irradiation was carried out at 808 nm with a powder density of 2 W/cm² for 2 min. *p<0.05 and **p<0.01 for comparing these two treatment groups. (C) The apoptosis of cells at 48 h after various treatments (Q1: dead cells; Q2: late apoptotic cells; Q3: early apoptotic cells; Q4: live cells). (D) The cell cycle distributions at 48 h after various treatments. The concentrations of IR780 and PTX were 1.5 and 5 μg/mL, respectively, and all experiments were repeated at least 3 times.

Abbreviations: DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; PDFI, pullulan coated IR780-loaded DOPE/PF68 complex nanocore; PDFP, pullulan coated paclitaxel-loaded DOPE/PF68 complex nanocore; PF68, Pluronic F68; PTX, paclitaxel; FITC, fluorescein isothiocyanate.