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SHH and cell division in the VZ of a neocortex. (a) In a wild-type brain, radial glial cells (red) divide via proliferative SCD (left) to generate two radial glial cells, neurogenic SCD (middle) to create two neurons (blue) or ACD (right) to produce a radial glial cell and a neuron. (b) Upon SHH activation in a Ptch−/− mutant, radial glial cells increase the frequency of proliferative SCD. The frequency of each division type is indicated
