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. 2017 Nov 3;7(11):e017387. doi: 10.1136/bmjopen-2017-017387

Table 7.

Effect-to-treatment analysis: 15% attenuation model estimation

No Study MAST p Value PNC CEST CENC METR EER p Value CNTM
1 2 3 4 5 6 7
1 Brandes153 10.15 (9.24–11.06) 0.943 6 9.64 4 1.20 (0.74–1.95) 1.01 0.979 2.56 1.59 0.99 1.65 1.59 91
2 Strik155 8.40 (7.52–9.29) 0.015 6 7.98 4 0.81 (0.44–1.48) 0.68 0.302 −2.56 4.22 1.62 4.63 4.19 −2.64
3 Abacioglu156 7.34 (6.46–8.22) <0.001 6 6.98 4 0.57 (0.37–0.89) 0.48 0.016 −1.59 −4.22 2.62 −47.9 592 −1.62
4 Berrocal157 5.63 (4.76–6.51) <0.001 6 5.35 3 0.19 (0.08–0.49) 0.16 <0.001 −0.99 −1.62 −2.62 −2.48 −2.63 −1.00
5 WA (1–4) 7.44 (6.56–8.31) <0.001 6 7.07 4 0.59 (0.40–0.88) 0.50 0.015 −1.65 −4.63 47.9 2.48 44.3 −1.68
6 WA (2–4)* 7.34 (6.46–8.21) <0.001 6 6.97 4 0.57 (0.39–0.85) 0.48 0.011 −1.59 −4.19 −592 2.63 −44.3 −1.62
7 Sahinbas23 10.10 (9.10–11.10) 1.000 6 9.5 4 1.19 (0.59–2.40) 1.00 1.000 −91 2.64 1.62 1.00 1.68 1.62

*Main comparator.

CA, coefficient of attenuation; CENC, cost-effective number of cycles; CEST, cost-effective survival time; EER, effect enhancement rate; MAST, maximal attainable survival time; METR, median effect-to-treatment ratio; WA, weighted average; PNC, peak number of cycles.