Table 1.

Clinical summary of cases with membranoproliferative glomerulonephritis with positive eye exam.

	Case 1	Case 2	Case 3	Case 4
Age at first presentation	52	14	24	52
Gender	Female	Female	Male	Female
Race	Caucasian	Caucasian	Caucasian	Caucasian
Systemic disease	Diabetes mellitus; HTN	Diabetes mellitus; HTN	HTN	Monoclonal gammopathy
Type of MPGN	II*	Probably Primary**	II*	Probably Secondary*
Duplication of basal lamina of glomerulus	Yes	Yes	Yes	Yes
Antibodies present (IgG, IgM)	No	Yes	Yes	Yes
Complement present (C3)	Yes	Yes	Yes	Yes
Smoker	No	No	No	No
Age at dx of MPGN	50	28	24	55
HTN duration (years)	2	26	3	No HTN
Hemoglobin level serum	11.0	13.0	11.1	NA
Serum creatinine mg/dl	2.2	1.6	1.5	5.0
Oral corticosteroid intake	Yes	Yes	No	Yes
Mycophenolate mofetil intake	Yes	Yes	No	Yes
Age at first diagnosis of drusen	50	29	24	55
Initial vision	20/25 OD 20/20 OS	20/20 OD 20/30 OS	20/20 OD 20/20 OS	20/60 OD 20/40 OS
Final vision	20/25 OD 20/20 OS	20/30 OD 20/30 OS	20/20 OD 20/20 OS	20/200 OD 20/40 OS
Length of follow-up (years)	1.5	37	2.5	2.0
Drusen type (laminar)	Yes	Yes	Yes	Yes
Drusen location	Diffuse till equator	Diffuse till equator	Macula	Posterior pole
Drusen size (microns)	50	200	25	50
Fundus Autofluorescence	Yes	Yes	No	Yes
Diffuse thickening of Bruch's membrane	Yes	Yes	No	Yes
Serous retinal detachment	No	Yes	No	Yes
RPE detachment	No	Yes	No	Yes
Choroidal new vessel	No	No	No	No

Abbreviations: HTN, systemic hypertension; MPGN, membranoproliferative glomerulonephritis; NA, not assessed; OD, right eye; OS, left eye, RPE, retinal pigment epithelium (one asterisk refers to documentation by transmission electron microscopy, and 2 asterisks refers to negative workup for secondary causes of MPGN).