Table 3B.
Change in PAI-1 after 4 years versus Serial Change in Clinical Characteristics
| Quartile 1 (n=684) | Quartile 2 (n=685) | Quartile 3 (n=685) | Quartile 4 (n=684) | Linear Trend P value | Quadratic Trend P-Value | |
|---|---|---|---|---|---|---|
| Change in PAI-1 | −12.6 ± 13.0 | 0.6 ± 1.7 | 6.7 ± 2.1 | 22.4 ± 13.6 | ||
| Age (years) | 4.0 ± 0.6 | 4.0 ± 0.5 | 4.1 ± 0.6 | 4.1 ± 0.6 | 0.06 | 0.68 |
| Male (%) | 45.9 | 41.0 | 45.1 | 46.6 | 0.47 | 0.10 |
| Systolic Blood Pressure (mmHg) | 2 ± 17 | 3 ± 15 | 3 ± 15 | 4 ± 16 | 0.005 | 0.81 |
| Antihypertensive Therapy (%) | 8.5 | 7.9 | 10.4 | 9.8 | 0.26 | 0.99 |
| Diabetes Mellitus (%) | 1.9 | 1.4 | 2.0 | 5.1 | 0.002 | 0.015 |
| Cigarette Smokers (%) | −3.3 | −3.2 | −2.4 | −0.4 | 0.69 | 0.29 |
| Total cholesterol (mg/dl) | −4 ± 31 | 0.3 ± 28 | 3 ± 27 | 6 ± 42 | <0.001 | 0.63 |
| HDL cholesterol (mg/dl) | 2.6 ± 9.3 | 1.7 ± 9.2 | 0.2 ± 8.8 | −0.5 ± 9.0 | <0.001 | 0.87 |
| Triglycerides (mg/dl) | −23 ± 93 | −6 ± 62 | −3 ± 74 | 7 ± 218 | <0.001 | 0.51 |
| BMI (m2/kg) | −0.1 ± 2.1 | 0.3 ± 1.5 | 0.7 ± 1.5 | 1.3 ± 2.3 | <0.001 | 0.48 |
| Baseline PAI-1 (ng/ml) | 34.3 ± 21.5 | 16.7 ± 10.7 | 16.7 ± 10.6 | 20.2 ± 12.3 | <0.001 | <0.001 |
Mean ± Standard Deviation