Fig. 4. schematic model of the antimony-resistance mechanism in promastigotes of Leishmania infantum isolated from refractory patients from Brazil. In drug resistant isolates, higher thiol metabolism of thiol results in thiol-metal complex formation and drug inactivation. Additionally, the thiol component can buffer SbIII-induced ROS. Thereby, the parasites can survive at high concentrations of SbIII.
