Table 9. Evaluation of the diagnostic accuracy of the forced oscillation parameters in detecting respiratory alterations in patients with sickle cell anemia and normal and abnormal spirometric exams.
Values of area under the curve (AUC), sensitivity (Se), specificity (Sp) for the optimal cut-off points obtained using receiver operating characteristic (ROC) curves.
| R0 | Rm | R4 | S | Xm | fr | Cdyn | Z4 | |
|---|---|---|---|---|---|---|---|---|
| Normal exam | ||||||||
| AUC | 0.67 | 0.63 | 0.62 | 0.77 | 0.62 | 0.69 | 0.66 | 0.63 |
| Se (%) | 61.90 | 52.38 | 57.14 | 66.67 | 57.14 | 66.67 | 61.9 | 57.14 |
| Sp (%) | 60.87 | 56.52 | 52.17 | 60.87 | 60.87 | 65.22 | 60.87 | 56.52 |
| Cut-off | 3.07 | 3.02 | 2.93 | -14.67 | 0.66 | 10.53 | 0.02 | 3.83 |
| Abnormal exam | ||||||||
| AUC | 0.78 | 0.74 | 0.75 | 0.76 | 0.73 | 0.73 | 0.79 | 0.78 |
| Se (%) | 79.17 | 66.67 | 66.67 | 70.83 | 66.67 | 62.5 | 75 | 75 |
| Sp (%) | 73.91 | 69.57 | 65.22 | 69.57 | 65.22 | 60.87 | 73.91 | 73.91 |
| Cut-off | 3.23 | 3.33 | 3.26 | -15.69 | 0.5 | 10.51 | 0.01 | 4.22 |