Table 2. Summary of C5aR expression and characterization of C5aR-positive cells in the synovium from patients with RA, OA, PsA and from non-inflammatory controls.
| Cell type | RA1 Joint replacement |
RA1 Synovectomy |
OA1 | PsA1 | Non-inflammatory control1,2 |
|---|---|---|---|---|---|
| C5aR+ cells | 28/35 | 8/8 | 11/15 | 10/10 | 3/7* |
| C5aR+MPO+ neutrophils | 11/19 | 6/8 | 7/27 | 7/8 | 0/7 |
| C5aR+CD68+ macrophages | 11/16 | 7/7 | 10/21 | 7/7 | 3/4* |
| C5aR+CD3+ T cells | 0/19 | ND | 0/27 | 0/2 | 0/5 |
1Number of positive samples/total number of samples included in the study.
2Histopathologically classified as being within normal limits.
Abbreviations: ND: Not done; OA: Osteoarthritis; PsA: Psoriatic arthritis; RA: Rheumatoid arthritis.
*Single or double-positive cells present in synovial lining.