Table 1. Potential target genes with gene amplification, overexpression and oncogenic function.
| DNA amplification# | mRNA overexpression## Fold change (T/N) |
Function | |
|---|---|---|---|
| Amplification peak | Potential Target Genes | ||
| 20q13.2 | ZNF217 | 6.28 | Cell proliferation, transcription regulation, apoptosis inhibition |
| 17q22 | APPBP2 | 3.92 | Meiosis regulation |
| TMEM49 | 2.47 | Cell motility, cell invasion, apoptosis inhibition | |
| 3q26.31 | PRKCI | 6.70 | Cell growth, cell migration and invasion, apoptosis inhibition |
| ECT2 | 4.72 | Cell growth and proliferation | |
| 19q12 | GPI | 2.72 | Cell proliferation, glucose metabolism, DNA replication |
| PSENEN | 4.50 | Cell proliferation | |
| CEBPG | 3.03 | Transcription regulation | |
| 8q11.23 | MCM4 | 2.15 | Cell growth , cell cycle, DNA replication |
| PRKDC | 3.73 | DNA repair, cell proliferation | |
| UBE2V2 | 4.14 | DNA repair and replication | |
| 2q13 | PAX8 | 7.21 | Cell division, cell proliferation, apoptosis inhibition |
| 8q24.3 | PTK2 | 2.87 | Cell invasion, cell growth, angiogenesis, DNA repair and replication |
| 1q44 | ADSS | 2.63 | Purine metabolism |
| ARID4B | 3.52 | Cell growth, translation regulation | |
| FH | 3.13 | Cell growth, purine metabolism | |
| HNRNPU | 3.07 | Chromatin remodeling, cell proliferation | |
| MTR | 3.08 | DNA replication | |
| 4p16.3 | FGFR3 | 12.9 | Cell growth, apoptosis inhibition, angiogenesis |
# Copy number variation determined by aCGH on 12 CCOC cell lines.
## mRNA differentially expression between 10 CCOC tumor specimens (T) and 10 normal ovarian surface epithelium specimens (N) by expression microarray analysis.