Figure 3. Ligand mediated activation of ERβ suppresses cell cycle progression.

Flow cytometry analysis of MDA-MB-231-ERβ cells following doxycycline induction of ERβ, as well as ligand mediated activation of ERβ with 1 nM E2 and 10 nM LY500307 for 24 hours or 5 days. A. Raw peaks and B. quantitation of cells in each phase of the cell cycle following indicated treatments. * Denotes significance at the P ≤ 0.05 level compared with vehicle control.