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. 2017 Oct 16;8(57):96604–96614. doi: 10.18632/oncotarget.21852

Figure 1. Circulating betatrophin levels and ROC curve analysis in the study cohort.

Figure 1

(A) Circulating betatrophin levels in normal and PCOS women with IR (vs. controls: ** P < 0.01). (B) Circulating betatrophin levels according to BMI (normal-weight: BMI < 25kg/m2 and overweight/obese: BMI >25 kg/m2, vs. normal weight: **P < 0.01). (C) Prevalence of elevated PCOS in different quartiles of betatrophin: quartile 1, <0.33μg/L; quartile 2, 0.33-0.49μg/L; Quartile 3, 0.49-0.62μg/L; Quartile 4, >0.62μg/L (vs. quartile 1: *P <0.05, **P <0.01). (D) ROC curve analyses for the prediction of IR according to the betatrophin levels. (E) Circulating betatrophin levels in both IR and healthy women during EHC (vs. controls: ∆P<0.01, #P<0.05; vs. 0 minutes: *P <0.01). (F) Circulating betatrophin levels in PCOS women with IR pre- and post-metformin treatment (vs. baseline: **P<0.01). (G) Circulating betatrophin levels during EHC pre- and post-metformin treatment (vs. baseline: ∆P < 0.01, #P < 0.05; vs. 0 min: *P < 0.01).