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. 2017 Oct 16;8(57):96604–96614. doi: 10.18632/oncotarget.21852

Figure 3. The effects of insulin, metformin and rosiglitazone on the expression of betatrophin in mouse hepatocytes and the hepatocyte/macrophage co-culture systems.

Figure 3

(A-B) Dose- dependent effects of insulin on betatrophin mRNA (A) and protein(B) expression in mouse hepatocytes. (C-D) Dose-dependent effects of metforminin the presence of 100 nM insulin on betatrophin mRNA (C) and protein (D)expression in mouse hepatocytes. (E-F) Dose- dependent effects of rosiglitazone in the presence of 100 nM insulin on betatrophin mRNA (E) and protein (F) expression in mouse hepatocytes. (G-H) Betatrophin mRNA (G) and protein (H) expression in cell lysates from the hepatocyte/macrophage co-culture systems with or without rosiglitazone treatment in the presence of 100 nM insulin. (I-J) Betatrophin mRNA (I) and protein (J) expression in cell lysates from the hepatocyte/macrophage co-culture systems with or without metformin treatment in the presence of 100 nM insulin. Hep, hepatocytes; Mac, macrophage; Ros, rosiglitazone. Data are presented as the means ± SE. * P < 0.05, **P < 0.01.