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. 2017 Oct 16;8(57):96604–96614. doi: 10.18632/oncotarget.21852

Figure 4. The effects of betatrophinexpression on insulin signaling in hepatocytes with insulin stimulation.

Figure 4

Primary hepatocytes were infected with or without recombinant adenovirus vectors encoding betatrophin (A-C) or shRNA specific (D-F) or for betatrophin control green fluorescent protein (Ad-GFP) for 48 h, followed with 100 nmol/L insulin stimulation for 10 min. Western blot was conducted to examine the phosphorylation levels of InsR (A and D), AKT (B and E) and IRS-1 (C and F). Data are presented as the means ± SD. * P < 0.05, ** P < 0.01 vs. control.