Table 2. Mutational profiling of 1006 lung cancers and variant allele frequency.
| Lung cancer | Variant allele frequencya | |||
|---|---|---|---|---|
| (n = 1006) | ≤ 5% | ≤ 10% | ≤ 20% | |
| AKT1 | 4 (0.4%) | NA | NA | NA |
| BRAF | 63 (6.3%) | 7.7% | 25% (P = 0.009) | 63% (P < 0.001) |
| EGFR | 187 (19%) | 2.2% | 7.8% (P = 0.07) | 27% (P = 0.003) |
| ERBB2 | 13 (1.3%) | NA | NA | NA |
| KRAS | 362 (36%) | 4.1% | 13% | 39% |
| NRAS | 11 (1.1%) | NA | NA | NA |
| PIK3CA | 37 (3.7%) | 13% | 37% (P < 0.001) | 63% (P = 0.003) |
NA: not analyzed.
aPercentage of mutations with variant allele frequencies of ≤ 5%, ≤ 10% and ≤ 20%. Data of all 1074 specimens were included for analysis of variant allele frequencies. P values were analyzed by comparing with KRAS variant allele frequencies.