Table 4. Doublet (compound) EGFR mutations in 1006 lung cancers.
| mut 1a | Exon (mut 1) | mut 2a | Exon (mut 2) |
|---|---|---|---|
| p.G724A (17%) | 18 | p.R108G (16%) | 3 |
| p.G719C (44%) | 18 | p.A289V (45%) | 7 |
| p.G724S (50%) | 18 | p.A289V (39%) | 7 |
| p.G719A (23%)b | 18 | p.I706T (22%)b | 18 |
| p.G719A (44%)b | 18 | p.E709A (44%)b | 18 |
| p.G719A (26%)b | 18 | p.E709K (25%)b | 18 |
| p.G719C (61%)b | 18 | p.E709A (60%)b | 18 |
| p.G719A (36%) | 18 | p.S768I (46%) | 20 |
| p.G719A (63%) | 18 | p.G779C (77%) | 20 |
| p.G719A (40%) | 18 | p.S768I (46%) | 20 |
| p.G719A (19%) | 18 | p.T790M (16%) | 20 |
| p.G719C (77%) | 18 | p.S768I (76%) | 20 |
| p.G719C (41%) | 18 | p.S768I (42%) | 20 |
| p.G719S (11%) | 18 | p.S768I (10%) | 20 |
| p.G719S (46%) | 18 | p.S768I (42%) | 20 |
| p.G719A (60%) | 18 | p.L861Q (66%) | 21 |
| p.G719D (21%) | 18 | p.L861Q (19%) | 21 |
| p.G719S (31%) | 18 | p.L861Q (25%) | 21 |
| p.L747_T751del (30%)b,c | 19 | p.K754Q (30%)b,c | 19 |
| p.L747_P753delinsS (12%) | 19 | p.T790M (7.3%) | 20 |
| p.L858R (16%) | 21 | p.R108K (21%) | 3 |
| p.L858R (14%) | 21 | p.R108K (21%) | 3 |
| p.L858R (15%) | 21 | p.A289V (18%) | 7 |
| p.L861Q (75%) | 21 | p.A289T (78%) | 7 |
| p.L858R (10%) | 21 | p.E709K (13%) | 18 |
| p.L858R (29%) | 21 | p.I744M (36%) | 19 |
| p.L858R (7.6%) | 21 | p.T790M (65%) | 20 |
| p.L858R (20%) | 21 | p.S768I (24%) | 20 |
| p.L861Q (17%) | 21 | p.T790M (19%) | 20 |
aPercentage in the parenthesis indicates variant allele frequency.
bLocated within the same allele.
cDouble EGFR mutations seen in this tumor may also be categorized as a complex exon 19 deletion (c.2238_2260delinsATCTCCGC, p.L747_K754delinsSPQ).