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. 2017 May 20;8(57):96697–96709. doi: 10.18632/oncotarget.18043

Figure 4. Decrease of DNMT1 after riluzole treatment.

Figure 4

(A) Real-time PCR showed that the treatment of 11SP and 64SP cells with 50 µM riluzole for 72 h decreased DNMT1 mRNA expression. (B) KDM1A mRNA level did not change after 72 h. (C) A decrease in the DNMT1 protein level was confirmed, which was represented by the western blot with anti-DNMT1 antibody 72 h after the treatment. (D) Statistical analysis of DNMT1 protein expression from three independent experiments was performed using two-sided t-tests for two-group comparisons (*p < 0.05, **p < 0.01, ***p < 0.001).