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. 2017 May 22;8(57):96710–96724. doi: 10.18632/oncotarget.18073

Figure 6. Efficacy of BKM120, RAD001 and ruxolitinib, single or in triple combination, in JAK2V617F knock-in mice.

Figure 6

Animals received treatment for 16 days before sacrifice; control mice received vehicle only with the same schedule as treated ones. 10 mice for each treatment cohort were analyzed. (A) Effects of triple treatment on spleen size (upper panel) and spleen index (calculated as ratio of spleen and body weight x100) compared to other treatment groups and controls. (B) Histopathology of the spleen and bone marrow in control and treated mice. Picture were taken with a LEICA DM LS2 microscope using a N-Plan × 20 objective. (C) The number of reticulocytes per 10 high power fields in peripheral blood smears. (D) The number of white blood cells and platelets in the peripheral blood of mice treated with drugs combination; values in mice receiving each single drug were comparable to controls and are not shown. All P values were determined by unpaired two-tailed Student’s T test and confirmed by BootstRatio test on fold change data (*P < 0.05, **P < 0.01).