Table 1. Characteristics of never users and ever users of sitagliptin.
Variable | Never users (n = 39195) | Ever users (n = 39195) | P-value | SD | ||
---|---|---|---|---|---|---|
n | % | n | % | |||
Age (years) | 55.81 ± 10.16 | 56.19 ± 9.97 | < 0.0001 | 3.83 | ||
Diabetes duration (years) | 6.60 ± 2.74 | 6.63 ± 2.79 | 0.1764 | 0.53 | ||
Sex (men) | 21331 | 54.42 | 21282 | 54.30 | 0.7253 | −0.16 |
Hypertension | 30121 | 76.85 | 30434 | 77.65 | 0.0077 | 1.90 |
Chronic obstructive pulmonary disease | 16590 | 42.33 | 16639 | 42.45 | 0.7232 | 0.20 |
Stroke | 9056 | 23.10 | 9086 | 23.18 | 0.7994 | 0.14 |
Nephropathy | 8821 | 22.51 | 8940 | 22.81 | 0.3100 | 0.81 |
Ischemic heart disease | 14965 | 38.18 | 14881 | 37.97 | 0.5367 | −0.37 |
Peripheral arterial disease | 8005 | 20.42 | 8162 | 20.82 | 0.1658 | 1.09 |
Eye disease | 12766 | 32.57 | 12785 | 32.62 | 0.8849 | 0.12 |
Obesity | 2955 | 7.54 | 2826 | 7.21 | 0.0779 | −1.47 |
Dyslipidemia | 32800 | 83.68 | 32978 | 84.14 | 0.0836 | 1.39 |
Acute pancreatitis | 198 | 0.51 | 201 | 0.51 | 0.8803 | 0.10 |
Tobacco abuse | 1405 | 3.58 | 1491 | 3.80 | 0.1034 | 1.21 |
Alcohol−related diagnoses | 2134 | 5.44 | 2071 | 5.28 | 0.3179 | −0.68 |
Gingival and periodontal diseases | 35017 | 89.34 | 34974 | 89.23 | 0.6195 | −0.38 |
Oral mucosal lesions | 866 | 2.21 | 841 | 2.15 | 0.5407 | −0.53 |
Statin | 27403 | 69.91 | 27767 | 70.84 | 0.0044 | 2.11 |
Fibrate | 16169 | 41.25 | 16420 | 41.89 | 0.0689 | 1.47 |
Angiotensin converting enzyme inhibitor/angiotensin receptor blocker | 27046 | 69.00 | 27534 | 70.25 | 0.0002 | 2.68 |
Calcium channel blocker | 20072 | 51.21 | 20550 | 52.43 | 0.0006 | 2.47 |
Sulfonylurea | 21967 | 56.05 | 23149 | 59.06 | < 0.0001 | 5.85 |
Metformin | 29817 | 76.07 | 30018 | 76.59 | 0.0912 | 0.82 |
Insulin | 2350 | 6.00 | 2186 | 5.58 | 0.0121 | −2.23 |
Acarbose | 4444 | 11.34 | 4257 | 10.86 | 0.0335 | −1.60 |
Pioglitazone | 2588 | 6.60 | 2577 | 6.57 | 0.8742 | 0.22 |
Rosiglitazone | 1770 | 4.52 | 1453 | 3.71 | < 0.0001 | −4.07 |
Aspirin | 21560 | 55.01 | 21938 | 55.97 | 0.0066 | 1.89 |
Ticlopidine | 1253 | 3.20 | 1323 | 3.38 | 0.1608 | 0.99 |
Clopidogrel | 3098 | 7.90 | 3016 | 7.69 | 0.2748 | −0.81 |
Dipyridamole | 12029 | 30.69 | 12387 | 31.60 | 0.0058 | 2.10 |
Age and diabetes duration are expressed as mean ± standard deviation
SD: standardized difference