Table 3. Incidence rates of oral diseases and hazard ratios by sitagliptin exposure.

Sitagliptin use	Cases followed	Incident cases of oral diseases	Person-years	Incidence rate (per 100,000 person-years)		Hazard ratio		95% Confidence interval		P-value
Never users	4764	610	8169.96	7466.38		1.000
Ever users	4764	616	8275.77	7443.41		0.999		(0.892−1.118)		0.9797
Cumulative duration (months)
Non-users	4764	610	8169.96	7466.38		1.000
< 6.87	1573	278	2385.93	11651.65		1.634		(1.416−1.885)		< 0.0001
6.87–14.93	1532	214	2437.67	8778.89		1.214		(1.038−1.419)		0.0154
> 14.93	1659	124	3452.18	3591.94		0.446		(0.368−0.542)		< 0.0001
Cumulative dose (mg)
Non-users	4764	610	8169.96	7466.38		1.000
< 17,600	1569	269	2376.27	11320.26		1.591		(1.377−1.838)		< 0.0001
17,600–40,500	1574	222	2544.72	8723.96		1.198		(1.027−1.399)		0.0217
> 40,500	1621	125	3354.79	3726.02		0.464		(0.383−0.563)		< 0.0001

Oral diseases include “gingival and periodontal diseases” and/or “oral mucosal lesions”