Table 5. Pathway analysis on significant metabolites with EGR1-siRNA versus EGR1-control siRNA in LCC9 cells.
| Name of pathway | Source of pathway | Number of significant metabolites in pathway/ Number of metabolites in pathway | p-value | q-value |
|---|---|---|---|---|
| Biosynthesis of unsaturated fatty acids - Homo sapiens (human) | KEGG | 4/32 | < 0.001 | 0.042 |
| Linoleic acid metabolism - Homo sapiens (human) | KEGG | 3/19 | < 0.001 | 0.042 |
| Signal Transduction | Reactome | 6/169 | < 0.001 | 0.042 |
| Heparan sulfate/heparin (HS-GAG) metabolism | Reactome | 3/21 | < 0.001 | 0.042 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | Reactome | 2/5 | < 0.001 | 0.042 |
| Activation of Gene Expression by SREBP (SREBF) | Wikipathways | 2/5 | < 0.001 | 0.042 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | Wikipathways | 2/5 | < 0.001 | 0.042 |
| Glycosaminoglycan metabolism | Wikipathways | 3/27 | < 0.001 | 0.042 |
| Leishmaniasis - Homo sapiens (human) | KEGG | 2/6 | < 0.001 | 0.042 |
| Circadian Clock | Wikipathways | 2/6 | < 0.001 | 0.042 |
| triacylglycerol degradation | HumanCyc | 3/29 | < 0.001 | 0.042 |
| Defective SLC26A2 causes chondrodysplasias | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective PAPSS2 causes SEMD-PA | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective B4GALT7 causes EDS_ progeroid type | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective B3GAT3 causes JDSSDHD | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective CHSY1 causes TPBS | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective CHST3 causes SEDCJD | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective CHST14 causes EDS_ musculocontractural type | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective CHST6 causes MCDC1 | Reactome | 3/29 | < 0.001 | 0.042 |
| Diseases associated with glycosaminoglycan metabolism | Reactome | 3/29 | < 0.001 | 0.042 |
| Glycosaminoglycan metabolism | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective EXT2 causes exostoses 2 | Reactome | 3/29 | < 0.001 | 0.042 |
| Defective EXT1 causes exostoses 1_ TRPS2 and CHDS | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS IX - Natowicz syndrome | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS I - Hurler syndrome | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS II - Hunter syndrome | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS IIIA - Sanfilippo syndrome A | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS IIIB - Sanfilippo syndrome B | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS IIIC - Sanfilippo syndrome C | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS IIID - Sanfilippo syndrome D | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS IV - Morquio syndrome A | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS IV - Morquio syndrome B | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS VI - Maroteaux-Lamy syndrome | Reactome | 3/29 | < 0.001 | 0.042 |
| MPS VII - Sly syndrome | Reactome | 3/29 | < 0.001 | 0.042 |
| Mucopolysaccharidoses | Reactome | 3/29 | < 0.001 | 0.042 |
| phospholipases | HumanCyc | 3/30 | < 0.001 | 0.044 |
| sphingomyelin metabolism/ceramide salvage | HumanCyc | 3/30 | < 0.001 | 0.044 |
| sphingosine and sphingosine-1-phosphate metabolism | HumanCyc | 3/36 | < 0.001 | 0.063 |
| the visual cycle I (vertebrates) | HumanCyc | 3/36 | < 0.001 | 0.063 |
| Transport of fatty acids | Reactome | 2/9 | < 0.001 | 0.070 |
| Transcriptional Regulation of White Adipocyte Differentiation | Wikipathways | 2/9 | < 0.001 | 0.070 |
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | Wikipathways | 2/9 | < 0.001 | 0.070 |
The pathway analysis was performed using tool http://impala.molgen.mpg.de/ . The pathways enriched at q-value < 0.1 are shown.