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. 2017 Sep 11;8(57):96993–97008. doi: 10.18632/oncotarget.20823

Figure 4. IL-17A-promoted MSC2 polarization related with new bone formation of PGISp mice.

Figure 4

Values are the mean ± SEM (all n = 3). *P < 0.05, **P < 0.01. (A) Appearances of PGISp mice without new bone formation (NBF-PGISp) at 5 month old. (B) Analysis for eyes of NBF-PGISp mice in slit lamp microscope (Original magnification 400×). (C–D) MicroPET-CT analysis for NBF-PGISp mice. (E) New bone formation and/or tissue hyperplasia of PGISp mice (NBF+PGISp) at 7 month old by HE staining. (F) Flow cytometry of PBMCs-derived macrophage and CD4+T cells of NBF+PGISp mice. (G) Immunohistochemistry staining for NBF+PGISp mice. (H–I) The relative mRNA expression of factors related to MSC1/2 polarizations in PBMCs of NBF-PGISp mice (H) and lumbar of NBF+PGISp mice (I) by RT-qPCR.