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. 2017 Oct 19;8(57):97304–97312. doi: 10.18632/oncotarget.21937

Figure 4. Single amino acid variants associated with GBM.

Figure 4

(A) the numbers of proteins and peptides in the standard protein library (Standard) and our customized SAAV database of GBM (SAAVs); and the numbers of mutated proteins/peptides uniquely identified in this study (Mut). Standard database included 36858 peptides in 4834 proteins; mean 7.6 peptides per protein and our customized mutation database included 23405 mutated peptides in 2515 proteins; mean 9.3 mutated peptides per protein. We identified 3884 peptide mutations in 897 proteins; mean 4.3 mutated peptides per protein. (B) the number of samples with mutations in 14 peptides of 14 proteins in GBM and normal brain samples with 75-99% mutation rate. (C) the percent of proteins with different mutation numbers among those with SAAVs that were exclusively observed in GBM (100% mutation rate). Blue, 1 SAAV; red, 2 SAAVs; green, 2-4 SAAVs; and purple, more than 4 SAAVs. (D) the number of mutation sites and cases of GBM for the 3 most frequently mutated proteins (MYH11, FN1 and SYNM). Red boxes indicate the mutation site and mutation cases in 8 GBM patients.