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. 2017 Oct 23;8(57):97313–97322. doi: 10.18632/oncotarget.21960

Figure 4. MiR-204 enhanced the cytotoxicity of DOX through decreasing the expression of SIRT1 in PCa.

Figure 4

(A) Effect of SIRT1 plasmid and siRNA on changing the expression level of SIRT1 in C4-2 and LNCaP cells. (B) Overexpression of SIRT1 abolished the effect of miR-204 on enhancing the DOX-induced (0.5 μM) cell death in C4-2 and LNCaP cells. *P<0.05 vs. DOX + NCO group, #P<0.05 vs. DOX + miR-204 group. (C) Knockdown of SIRT1 dramatically increased the cytotoxicity of DOX (0.5 μM) to C4-2 and LNCaP PCa cells. *P<0.05 vs. DOX + NCO group.