Table 2. Microparticulosome signature based on a color code: high (red) and low (green) levels of MPs (MPs/ μL of plasma), according to the occurrence or not of a thrombo-embolic event.
| Group A | Group B | ||
|---|---|---|---|
| Thrombo-embolic event | No thrombo embolic event | ||
| n | 19 | 99 | P value |
| Total MPs |
8989(a) [1157–2119000] (100%) |
5866 [865–355459] (100%) |
0.17 |
| Subpopulations | |||
| PMPs |
5021 [110–32515] (56%)(b) |
3543 [288–45959] (61%) |
0.28 |
| EMPs |
16 [1.1-1507] (0.2%) |
3 [0.6-2340] (0.05%) |
0.17 |
| EryMPs |
126 [0–6641] (1%) |
260 [0–13026] (4%) |
0.65 |
| LeuMPs |
3 [0–44] (0.03%) |
5 [0–2972] (0.08%) |
0.43 |
| Procoagulant MPs | |||
| TF positive |
107 [0–1164] (1%) |
94 [0–3980] (2%) |
0.48 |
| Fibrin positive |
143 [0–1125] (2%) |
40 [0–930] (0.7%) |
0.01 |
| Tumor MPs | |||
| PODOPLANIN positive |
37 [0–4060] (0.4%) |
49 [0–6456] (0.9%) |
0.24 |
| MUC1 positive |
0 [0–57] (0.07%) |
8 [0–6673] (0%) |
0.002 |
| CEA positive |
0 [0–284] (0%) |
21 [0–4497] (0.4%) |
<0.0001 |
| CA19-9 positive |
0 [0–786] (0%) |
31 [0–4337] (0.6%) |
0.01 |
(a) median (range); (b) percentage of MPs’ subtypes out of median total MPs; p<0.05 is considered as significant; Total MPs = Annexin V+ MPs; PMPs = platelet-derived MPs (Annexin V+/CD41+); EMPs = endothelial-derived MPs (Annexin V+/CD31+/CD41-);
EryMPs = erythrocyte-derived MPs (Annexin V+/ CD235a+); LeuMPs = leukocyte-derived MPs (Annexin V+/CD11b+/CD235a-); TF positive = Annexin V+/TF+;
Fibrin positive = Annexin V+/Fib+; MUC positive = AnnexinV+/MUC+; CEA positive = AnnexinV+/CEA+; CA 19-9 positive = Annexin +/CA19-9 +.