Table 2. Multivariate Cox proportional hazards regression analyses for the impact of surgery type on OS and DSS.

Characteristics	OS		DSS
	Adjusted HR (95% CI)	P value	No. (%)	Adjusted HR (95% CI)	P value
Surgery type (LR/LT)	0.39 (0.26-0.59)	<0.001	250 (50.9)/241 (49.1)	0.19 (0.10-0.35)	<0.001
Age (≤59/>59)	1.38 (0.97-1.97)	0.07	267 (54.4)/224 (45.6)	1.03 (0.62-1.71)	0.91
Sex (Male/Female)	1.18 (0.80-1.74)	0.41	376 (76.6)/115 (23.4)	1.21 (0.70-2.12)	0.50
Year of diagnosis		0.30			0.83
2004-2007	1 (Reference)		136 (27.7)	1 (Reference)
2008-2010	0.84 (0.56-1.25)	0.39	171 (34.8)	0.88 (0.48-1.60)	0.66
2011-2013	0.64 (0.36-1.14)	0.13	184 (37.5)	1.07 (0.48-2.41)	0.87
Grade		0.56			0.08
III+IV	1 (Reference)		64 (13.0)	1 (Reference)
II	0.76 (0.45-1.29)	0.32	258 (52.5)	0.47 (0.24-0.91)	0.03
I	0.75 (0.43-1.31)	0.32	169 (34.4)	0.54 (0.26-1.10)	0.09
Tumor size (mm)		0.57			0.31
≤20	1 (Reference)		160 (32.6)	1 (Reference)
21-30	1.23 (0.80-1.90)	0.34	149 (30.3)	1.44 (0.74-2.82)	0.28
31-50	1.04 (0.67-1.60)	0.87	182 (37.1)	1.65 (0.87-3.12)	0.12
AFP (Normal/ Elevated)	0.77 (0.54-1.09)	0.14	214 (43.6)/277 (56.4)	0.72 (0.43-1.20)	0.20
Fibrosis score (0-4/5-6)	0.54 (0.36-0.82)	0.003	133 (27.1)/358 (72.9)	0.37 (0.21-0.6)	0.001
Race			0.12		0.53
American Indian/Alaska Native	1 (Reference)		5 (1.0)	1 (Reference)
White	0.38 (0.11-1.26)	0.11	307 (62.5)	0.53 (0.07-4.09)	0.55
Black	0.42 (0.12-1.48)	0.17	53 (10.8)	0.69 (0.08-5.71)	0.73
Asian or Pacific Islander	0.27 (0.08-0.92)	0.04	126 (25.6)	0.40 (0.05-3.24)	0.39
Marriage status			0.98		0.69
Widowed	1 (Reference)		19 (3.9)	1 (Reference)
Married	1.04 (0.50-2.16)	0.92	322 (65.6)	1.27 (0.42-3.87)	0.68
Others	1.00 (0.47-2.11)	0.99	150 (30.5)	1.00 (0.33-3.07)	0.99

Abbreviation: OS, overall survival; DSS, disease-specific survival; HR, hazard ratio; CI, confidence interval; LR, liver resection; LT, liver transplantation; AFP, alpha fetal protein.