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. 2017 May 31;8(57):97683–97692. doi: 10.18632/oncotarget.18313

Table 1. Basic characteristics of two classes of estrogen receptors.

ESTROGEN RECEPTORS
Receptor group Intracellular receptors Rhodopsin-like family of seven-transmembrane G
protein-coupled receptors
Example ERα, ERβ GPR30
Localization Cytosol, Nucleus Plasma membrane,
Endoplasmic reticulum
Signaling pathway Genomic Non-genomic
Ligand 17β-Estradiol (E2) 17β-Estradiol (E2)

ER, estrogen receptor; GPR30, G protein-coupled receptor 30.