Table 1. Basic characteristics of two classes of estrogen receptors.
ESTROGEN RECEPTORS | ||
---|---|---|
Receptor group | Intracellular receptors | Rhodopsin-like family of seven-transmembrane G protein-coupled receptors |
Example | ERα, ERβ | GPR30 |
Localization | Cytosol, Nucleus | Plasma membrane, Endoplasmic reticulum |
Signaling pathway | Genomic | Non-genomic |
Ligand | 17β-Estradiol (E2) | 17β-Estradiol (E2) |
ER, estrogen receptor; GPR30, G protein-coupled receptor 30.