Figure 8. mspTMS-evoked short-latency neuronal responses differ with stimulus orientations.

(A) Examples of short-latency (1–6 ms) multiunit response in layer V of the CFA to suprathreshold mspTMS (120% MT) oriented in ML and PA direction. The suprathreshold ML stimulus evoked virtually no response in this time window, whereas the PA stimulus evoked strong periodic firing in the neuronal population. Note, all orientations discussed here refer to the orientation of induced current in the brain. (B–C) Average of short-latency normalized multiunit FR (binsize 0.5 ms) across all animals tested with the ML- (B) and PA- (C) oriented mspTMS at increasing intensities. Dashed lines, significance thresholds determined by the 2.5 or 97.5 percentile of the empirical distribution of baseline normalized multiunit FR (see Materials and methods for details).