Figure 1. Representative Brightfield (top row of each set) and SFI images (bottom row of each set) collected from experiments involving Hemoporfin-mediated PDT, at Day 0 pre-PDT and Days 3 and Day 7 after PDT. A) With a sub-therapeutic radiant exposure of 33 J/cm2, we did not observe shutdown or reduction in flow, and vascular structure remained intact. B) At 169J/cm2, we observed a change in the morphological structure of the vasculature with complete shutdown observed on Day 7. C) At 300 J/cm2, we observed complete vascular shutdown with presence of hemorrhage formation.
