Figure 2. Representative example of Hemoporfin-mediated PDT using clinical treatment parameters (100 mW/cm2 irradiance, 2 mg/kg drug concentration, and 134 J/cm2 radiant exposure). We observed acute vascular shutdown, followed by gradual recovery of blood flow in the affected vasculature. We assigned a “0” score to this specific experiment, as there was evidence of blood flow recovery. A) Color and B) Brightfield images of the window chamber, indicating that blood vessel structure changed only minimally throughout the seven-day monitoring period. C) SFI images display persistence of functional flow within the blood vessels of the window chamber. Flow was reduced through Day 3 and was restored on Day 7.
