a. Sampling location of genome sequences from Brazil and the Americas. Federal states in Brazil are coloured according to 5 geographic regions (lower inset). A red line surrounds the states surveyed by the ZiBRA mobile lab in 2016. State codes are PA=Pará, MA=Maranhão, CE=Ceará, TO=Tocantins, RN=Rio Grande do Norte, PB=Paraíba, PE=Pernambuco, AL=Alagoas, BA=Bahia, RJ=Rio de Janeiro, SP=São Paulo. Underlined states represent those from which sequences in this study were generated (upper inset). Publicly available sequences were also collated from non-underlined states. b. Confirmed and notified ZIKV cases in NE Brazil. Upper panel shows the temporal distribution of RT-qPCR+ cases detected during ZiBRA fieldwork. Only samples with known collection dates are included (n=138 out of 181 confirmed cases). Lower panel shows notified ZIKV cases in NE Brazil between 01 Jan 2015 and 19 Nov 2016 (n=122,779). The dashed line represents the average climatic vector suitability score for NE Brazil (Methods). The vertical arrow indicates date of ZIKV confirmation in NE Brazil/Americas1. c. Notified ZIKV cases in the Centre-West, Southeast, North, and South regions of Brazil (clockwise from top left). The dashed lines represent the average climatic vector suitability score for each region.