Table 2.
In vitro inhibitory concentration values that inhibits cell growth by x% (ICx) and combination index (CIx) analysis of various drug combination on ES-2-luc cells (n=3).
| Drug combination (weight ratio) | Paclitaxel | EpoB | 17-AAG | Rapamycin | EpoB/17 AAG (0.4:3) | 17-AAG/Rapamycin (3:1.5) Q | EpoB/Rapamycin (0.4:1.5) | EpoB/17-AAG/Rapamycin (0.4:3:1.5) |
|---|---|---|---|---|---|---|---|---|
| IC35 (nM) | 0.475±0.062 | 0.164±0.028 | 5.19±0.47 | 1.08±0.14 | 0.0806±0.0121 | 1.63±0.20 | 0.218±0.024 | 0.825±0.165 |
| IC50 (nM) | 3.10±0.53 | 0.427±0.047 | 98.9±12.9 | 27.4±1.4 | 0.538±0.048 | 30.5±4.0 | 1.39±0.21 | 3.00±0.69 |
| IC65 (nM) | 20.2±3.0 | 1.11±0.22 | 1880±43 0 | 698±91 | 3.59±1.04 | 570±108 | 8.82±0.79 | 10.9±2.2 |
| CI35 | – | – | – | – | 0.0790 | 0.605 | 0.569 | 0.798 |
| CI50 | – | – | – | – | 0.173 | 0.503 | 1.09 | 0.777 |
| CI65 | – | – | – | – | 0.434 | 0.427 | 2.61 | 1.03 |